Merck Interview Question: Example: Can Size Exclusion Chromatography by coupled with Mass Spectroscopy? (No) Why not?

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Merck

Example: Can Size Exclusion Chromatography by coupled with Mass Spectroscopy? (No) Why not?

Anonymous

Oct 16, 2018

Yes, it is possible if using volatile buffer and salt mobile phase

Anonymous

Jun 29, 2010

SEC using a high salt mobile phase, which is not compatible with Mass Spec. Mass Spec requires