At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re focused on the potential of science to address the unmet needs of patients around the world. We commit to those areas where we think we can really change the course of medicine and bring big new ideas to life.
The VP, Global Franchise Head, EGFR Franchise reports to the SVP, Global Head, Oncology Franchise and is part of the Global Oncology Leadership Team. They are responsible for leading the development and execution of the Franchise business plan and strategy globally. Their role is to meet revenue and earnings goals, increase the overall Oncology commercial ambition, and provide life-changing care to patients. The position has full P&L responsibility for the relevant Franchise globally.
The Global Franchise Head for EGFR Franchise (including Tagrisso and Orpathys) will have the opportunity to continue the development of one of AstraZeneca’s leading franchises in cancer care, leading the Global launches with the potential to help hundreds of thousands of patients and generate significant revenues for the company. In this role you’ll play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients’ lives, and truly change the paradigm of care in cancer.
The position will use strategic thinking to assess a range of variables including market trends and opportunities, competition, research progress, etc., to craft strong near- and long-term strategies for the EGFR Franchise. This requires strong analytical skills combined with a strong market orientation to identify breakthrough opportunities.
Accountable for overall Tagrisso and Orpathys commercial strategies across all indications.
Develop resources and programs to support launches.
Lead Integrative Business Team(s) to manage the life cycle of our medicines including a strong focus on Business development
Deliver and execute Phase 3/pre-launch marketing strategy & execution plan. Execute against plan
Lead and deliver commercial strategy for multiple additional indications (lifecycle management)
Work with extended team to deliver a sustainable pricing and access strategy for multiple indications
Successful P&L Management experience.
Experience with revenue forecasting, expense management, business case development, including setting market price and management/communication of brand performance. Working knowledge of the business of oncology and regularly communicate performance updates/forecasts to senior leadership.
Track record of strong cross-functional collaboration and experience gaining partner alignment to move key initiatives forward. Gain alignment on critical issues/initiatives hold cross-functional partners accountable, including across Oncology Franchises.
Consistent track record of attracting and developing diverse teams and optimizing team performance in direct and matrixed leadership roles. Experience in defining organizational size, structure and capabilities based on long term business objectives for both Sales and Marketing. Ability to establish clear a Cancer Franchise vision and purpose and communicate it with passion and authenticity to the organization to shape culture.
Experience leading development of oncology brands and/or oncology strategies which are founded on clear customer and market insights. Experience working in and/or leading customer facing roles. Able to serve as thought partner to Cancer Global Product and Portfolio Strategy team and brand directors to define the development of future strategic direction for the franchise and communicate vision across all stakeholder groups.
Comprehensive understanding of the oncology space as well as the clinical profile of our brands, oncology and competitor products (current & future) to shape life-cycle planning and management and interact meaningfully with scientific community and patient advocacy groups.
Focuses on delivering high-impact opportunities at scale by implementing customer-specific approaches. Experience in building as well as shaping markets. Strong Business development and critical thinking to help drive the growth of our EGFR Franchise beyond the LoE timelines.
Able to actively engage, inspire and create follower ship of diverse teams. Engenders trust, empowers team and has courageous conversations. Makes fair, impartial and informed talent decisions. Ability to assess and implement changes to franchise go-to-market model including size & structure of both sales and marketing teams.
Education
Bachelor’s degree required. Advanced degree preferred (MD,PhD, MBA)
Successful commercial experience including leading P&L for large commercial units, including launch/post-launch of oncology products
Strong critical thinking, judgement and influencing skills, to influence R&D to ensure strong commercial focus
Strong leadership attributes to set direction, generate commitment, balance short- and long-term needs, constructively resolve issues
Proven experience and knowledge of a broad base of external customers including patients, prescribers, payors, providers and in/out license partners.
Global and/or country brand marketing experience, capable of developing compelling business cases.
Outstanding written and oral communication skills, including the ability to effectively develop powerful marketing materials for our customers and to write and deliver effective presentations for senior internal stakeholders.
Strong critical thinking and judgement and influencing skills, to influence and lead across local markets to ensure strong executional commercial focus
Delivery of high-impact above-market and in-market customer facing/shaping initiatives
Effective interactions with internal & external customers and partners to drive success
Significant knowledge & experience of drug development, particularly from Phase II through commercialization and launch
Thorough understanding of pharmaceutical marketing to specialty care healthcare professional audiences
Thorough understanding of general business and core marketing principles and application to pharmaceutical market challenges
Thorough understanding of the development process and necessary commercial touch points with cross-functional global product team members
Sufficient understanding of technical risks and the implications for the commercial aspects to future brands
Strong understanding of clinical data and biological mechanisms to be able to interpret and effective communicate the science
Sufficient understanding of technical considerations of clinical development and regulatory submissions and the commercial implications
This position is based at our Gaithersburg, MD campus. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and bold world.
AstraZeneca offers an environment where you can thrive by working with new drugs, digital approaches, and ever-changing environments. Our pioneering value-based agreements and Innovative Value Strategy solutions lead the way in the industry. We are driven by our determination to ensure the value of our medicines is realized. Our dynamic environment encourages creativity in designing strategies and innovative access solutions. We thrive on co-creation and draw on diverse perspectives to overcome challenges. Join us to be part of a team that is passionate about making a meaningful impact on patient outcomes.
Ready to make a difference? to join our team!
The annual base pay for this position ranges from $329,683.20 - 494,524.80 USD. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Date Posted
24-Jul-2026Closing Date
30-Jul-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
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