Required Qualifications:
A Ph.D. in Biochemistry with first authorship on at least 1 peer-reviewed research publication. Ph.D., DDS, DVM, JD, MD or equivalent.

Preferred Qualifications:
5 years of experience with recombinant protein expression in multiple expression systems, purification and characterization, in vitro protein stability assays, muscle cell culture (including generation of transgenic lines), , biochemical and migratory analyses, as well as implementation of intracellular tension sensors and image data analysis.

Position Description

Summary:
Duties as Postdoctoral Associate will principally include the design, implementation, and interpretation of experiments aimed at elucidating the effect of phosphorylations in the function and stability of dystrophin and utrophin proteins in the context of muscular dystrophy. Also, on assisting in tension sensing and mechanotransduction projects in diverse cell lines and disease models. The Postdoctoral Associate will also participate in the day-to-day supervision of technical staff (Junior Scientists) and undergraduate students integral to achieving project goals, in drafting manuscripts that communicate the study’s findings for publication in peer-reviewed manuscripts. Finally, the Postdoctoral Associate will actively participate in lab meetings and local seminars, and will represent/promote the project at relevant national meetings.

Essential Functions:
70%: Experimental design and implementation
Design and perform experiments to assess the phenotype of dystrophic mice expressing transgenic dystrophin molecules bearing disease-causing missense mutations.
10% % 10 Training/supervision of technicians and undergraduate students
Train new technical staff in standard phenotype assessment and supervise data acquisition on a day-to-day basis
15% Drafting extramural research proposals and manuscripts reporting study results
Will work with direct supervisor to plan and draft research grants to continue project as well as manuscripts reporting study results
5% Participation in seminars, journal clubs and symposia
Will present at least 1 formal seminar per year (locally or at a relevant national meeting) and attend relevant local seminars and journal clubs

BMBB:
The department of Biochemistry, Molecular Biology and Biophysics is committed to understanding the molecular mechanisms of metabolic diseases and cancer; developing novel strategies in biocatalysis and biotechnology; and advancing knowledge through structural biology and molecular biophysics. We organize ourselves into research divisions with emphases on Chemical and Structural Biology, Metabolic and Systems Biology, Molecular Biology and Synthetic Biology and Biotechnology. We are housed in new buildings with state-of-the-art research and support facilities.

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The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.