Inhibitor Design: Apply computational tools (docking, molecular dynamics) or experimental methods to design and screen small-molecule, peptide, or fragment-……
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Job Summary:
The Xu Lab in the Department of Biomedical Sciences is seeking a motivated and skilled Postdoctoral Fellow to join our team. The candidate will lead a research project focusing on molecular microbiology of infectious diseases. One focus of this role involves inhibitor design and validating these targets. The ideal candidate will possess extensive hands-on experience in microbial construct design, genetic transformation, recombinant protein expression, and targeting those proteins with biochemical inhibitors.
Key Responsibilities:
Inhibitor Design: Apply computational tools (docking, molecular dynamics) or experimental methods to design and screen small-molecule, peptide, or fragment-based inhibitors against target proteins.
Assay Development: Establish biochemical, biophysical, and cellular assays to measure inhibitor binding affinity and functional enzyme inhibition.
Construct Cloning: Design and construct expression plasmids, genetic vectors, and CRISPR-based tools for bacterial/host systems.
Strain Engineering: Engineer microbial strains and mammalian cells.
Protein Expression: Purify target proteins using chromatographic methods.
Characterization: Perform biochemical characterization, Western blotting, ELISA, and functional assays to validate protein activity.
Location MUSOM - Marshall University School of Medicine Salary Range Salary is commensurate with experience and internal equity
Required Qualifications
Education
Ph.D. in Microbiology, Molecular Biology, Biochemistry, Medicinal Chemistry, or a closely related field.
Experience
Demonstrated experience in inhibitor design, structural biology, or biochemical assay development for target evaluation.
Proven expertise in molecular cloning techniques (Gibson assembly, restriction-based, PCR).
Hands-on experience with bacterial transformation and genetic manipulation.
Strong background in recombinant protein expression and purification.
Evidence of productivity: At least one first-author publication in a peer-reviewed journal.
Experience using structural biology or computational chemistry software (e.g., PyMOL, Schrödinger, AutoDock, Rosetta).
Experience with biophysical characterization techniques (e.g., SPR, ITC, MST).
Knowledge of bioinformatics tools for gene/protein analysis.
Preferred Qualifications
Education
Experience
Posting Detail Information
Posting Number MR0884 Open Date 07/23/2026 Close Date Open Until Filled Yes Special Instructions Summary
Please include the following with your application:
A cover letter detailing research experience and interest in the position.
The minimum salary is $43K and the max salary is $65K.
$43K – $65K/yr (Glassdoor est.)
$53K
/yr Median
Huntington, WV
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