First off was a technical telephone interview that lasted about half an hour and involved questions regarding OpenGL, computer graphics, and related things. They didn't seem to be looking for specific technical skills beyond the basics, it's probably more important to express yourself well and transmit enthusiasm.
The on site interview involved questions about things I didn't know the answer to, but again the purpose seemed to be how do I go about solving this problem, rather than whether I knew the answer or not.