Pros
The anchor of the Texas Medical Center (TMC). MDACC has 21,000 employees, 2,000 of whom are faculty (clinical and/or research). TMC has ~100,000 employees, same amount of office space as downtown Houston, and the world's largest parking concession. Cancer patients can get about equally great treatment at MDACC as any of the other top ten NCI designated cancer centers in the US - go to one of these, not Joe's for profit cancer center that happens to be in your town. Texas does not have a state income tax. Air conditioning bill in Houston can be less than heating & A/C in the north.
Cons
Lots of silos, not much communication between them. Competition can be as fierce within MDACC as it is between MDACC and other leading cancer centers. Don't drive on I-10 through downtown during heavy rains. Don't live in or near a low spot - prone to flooding. Culture & values: "We do things the Anderson way" = the same way for the past 20 years. If your prospective manager uses this phrase during your interview, don't take the job.