Pros
The staff in general are pretty helpful, atleast in the satellite campus at science park where I work most of the time. The talent here is great, and so is the student community. If you have a passion for science, this is a good place to be. Seminars are held pretty regularly, and the organisers invite a lot of reknowned folk to give talks. Time off policies are a bit weird ( in the not good sense) when you start off, but I've heard they get better with time. As always, if you're in the good graces of your higher up, you'll have more doors opened for you.
Cons
The bureaucracy is stifling, even though the said bureaucrats try and help you out as much as possible. It's pretty evident that MD Anderson was designed/built to run like a business, but is trying to put on a cloak of being an academic institution. Also their new drug testing policy (effective Jan 1st 2015, MD Anderson is going to become a tobacco free campus) feels like management is going down a slippery slope. Also, new workers have to undergo a LOT of training in paperwork and in general, there are a lot of forms to fill out before doing anything - that too on software systems that were out of date in the early 2000's